April 11, 2018

The microenvironment is crucial to successful satellite cell activation as well as repair and regeneration of muscle. Skeletal muscle has an inherent capacity to repair and regenerate following injury through activation of muscle stem/progenitor cells (satellite cells)...

April 4, 2018

Exercise training benefits the elderly and the young as well as men and women consistently with regard to stem cells / progenitor cells. Long-term resistance training can reverse satellite cell distribution in elderly muscle toward that of young muscle. Data demonstrat...

March 28, 2018

This is an important area for future research in order to optimize cell-based therapies for disease. The transient mobilization increase in HSPCs is consistent between both men and women and young and elderly populations. Diseased and elderly populations can benefit th...

March 21, 2018

Data suggest that the ideal training stimulus for increasing stem cell quantity involves moderate to high training intensity and frequency using weight-bearing exercise modalities. Another important finding is that the effects of exercise training on stem cell quantity...

March 15, 2018

Why the velodrome? First, to place this blog in some sort of "stem cell" world, I do believe that exercise and racing are helpful for my health and my stem cells (we'll review literature on exercise and stem cells in the forthcoming mini-series, Exercise...

March 8, 2018

INTRODUCTION

As we have seen in previous blog posts in this mini-series of obesity and stem cells, there is a chronic low-grade systemic inflammation (metabolic inflammation) in obesity. The proinflammatory condition of obesity is considered the main factor in the patho...

February 22, 2018

Image Source: Mayo Clinic 

INTRODUCTION

An hypothesis was offered roughly a decade ago that osteoporosis might be considered the obesity of the bone.(1) The reason I find this hypothesis so engaging and interesting is that because for years obesity and overweight were co...

February 12, 2018

INTRODUCTION

In this series on the impact of obesity upon stem cells, we have reviewed a bit of data on stem cells (and/or progenitor cells) from various sources and seen that the impact in terms of the numbers of cells and the cellular functions are influenced by obesi...

February 9, 2018

INTRODUCTION

As we saw in Obesity and Stem Cells, Part I, the impact of obesity could be variable depending upon the source of the stem cells. In this particular blog, we will focus upon haematopoietic stem and progenitor cells (HSPCs) in the bone marrow. For this, we a...

February 7, 2018

INTRODUCTION

Obesity is never a fun topic to discuss. In fact, even the discussion of the topic can be associated with "fat shaming." However, ignoring the realities of the effects of obesity is more shameful. Moreover, obesity has a special, and difficult, meaning for...

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